Methenamine hippurate
Hiprex, Methenamine Hippurate, Urex (methenamine hippurate) is a small molecule pharmaceutical. Methenamine hippurate was first approved as Urex on 1982-01-01. It is used to treat bacteriuria, cystitis, escherichia coli infections, and staphylococcal infections in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| urogenital diseases | D000091642 |
Trade Name
FDA
EMA
Hiprex, Urex (generic drugs available since 2016-07-05)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Methenamine hippurate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| UREX | Alvogen | N-016151 RX | 1982-01-01 | 1 products |
| HIPREX | Validus Pharmaceuticals | N-017681 RX | 1982-01-01 | 1 products, RLD |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| hiprex | New Drug Application | 2022-02-02 |
| methenamine hippurate | ANDA | 2024-09-24 |
Indications
FDA
EMA
Agency Specific
FDA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
18 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | 2 | — | 5 | 3 | 10 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | — | 2 | 3 | 6 |
| Recurrence | D012008 | — | — | — | — | — | 2 | 1 | 3 |
| Communicable diseases | D003141 | — | — | — | — | — | 1 | 2 | 3 |
| Cystitis | D003556 | EFO_1000025 | N30 | — | — | 1 | 1 | — | 2 |
| Reinfection | D000084063 | — | — | — | — | — | 1 | — | 1 |
| Female urogenital diseases | D052776 | — | — | — | — | — | 1 | — | 1 |
| Urogenital diseases | D000091642 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dysuria | D053159 | EFO_0003901 | R30 | — | — | 1 | — | — | 1 |
| Interstitial cystitis | D018856 | EFO_1000869 | N30.1 | — | — | 1 | — | — | 1 |
| Pelvic pain | D017699 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urinary retention | D016055 | HP_0000016 | R33 | — | 1 | — | — | — | 1 |
| Pelvic organ prolapse | D056887 | EFO_0004710 | — | — | 1 | — | — | — | 1 |
| Prolapse | D011391 | — | — | — | 1 | — | — | — | 1 |
| Spinal dysraphism | D016135 | EFO_1001210 | Q05 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Bacteriuria | D001437 | — | R82.71 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
| Catheter-related infections | D055499 | — | — | — | — | — | — | 1 | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 1 | 1 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | — | — | — | 1 | 1 |
| Lupus nephritis | D008181 | EFO_0005761 | — | — | — | — | — | 1 | 1 |
| Nephritis | D009393 | — | N05 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Methenamine hippurate |
| INN | — |
| Description | Hexamethylenetetramine is a polycyclic cage that is adamantane in which the carbon atoms at positions 1, 3, 5 and 7 are replaced by nitrogen atoms. It has a role as an antibacterial drug. It is a polycyclic cage, a polyazaalkane and a tetramine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C1N2CN3CN1CN(C2)C3.O=C(O)CNC(=O)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 100-97-0 |
| RxCUI | 6832 |
| ChEMBL ID | CHEMBL1201104 |
| ChEBI ID | — |
| PubChem CID | 4101 |
| DrugBank | DB06799 |
| UNII ID | — |
Target
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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387 adverse events reported
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